Uncontrolled on Metformin

69-year-old 5'10", 225-lb male  Type 2 diabetes diagnosed 9 years ago  Treated with metformin titrated to 850 mg t.i.d.  MI: 32.3  Fasting glucose: 150 mg/dL  2-hour postprandial glucose: 288 mg/dL  A1c: 8.0% Medical History:  Hypertension  Hypercholesterolemia

Use a drug that works synergistically with metformin Avoid drug therapy that would result in edema, weight gain, and an increased risk of hypoglycemia

STARLIX 120 mg in combination with metformin  Reduced metformin to 1000 mg b.i.d.  asting glucose reduced to 122 mg/dL  2-hour postprandial glucose reduced to 175 mg/dL  A1c reduced to 6.8%*

STARLIX added to metformin helped patient reach A1c goal * In clinical trials, when STARLIX was added to metformin there was a mean reduction of 0.6% A1c. Individual patient responses may vary.

Important Safety Information

STARLIX is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

STARLIX is contraindicated in patients with a known hypersensitivity to the drug or its inactive ingredients, in patients with type 1 diabetes, or in patients with diabetic ketoacidosis. Patients with ketoacidosis should be treated with insulin.

All oral blood glucose lowering drugs that are absorbed systemically are capable of producing hypoglycemia. Patients should be advised to take STARLIX 1 to 30 minutes prior to eating a meal and to skip the dose if the meal is missed.

STARLIX should be used with caution in patients with moderate to severe liver disease because such patients have not been studied.

The most common adverse events associated with STARLIX vs placebo were upper respiratory infection (10.5% vs 8.1%), back pain (4.0% vs 3.7%), flu symptoms (3.6% vs 2.6%), dizziness (3.6% vs 2.2%), arthropathy (3.3% vs 2.2%), and diarrhea (3.2% vs 3.1%).

Please see the full prescribing information.